TY - JOUR AU - Kosyan D.B., AU - Rusakova E.A., AU - Sizova E.A, AU - Yausheva E.V, AU - Miroshnikov S.A, PY - 2021/11/19 Y2 - 2024/03/28 TI - TOXIC EFFECT AND MECHANISMS OF NANOPARTICLES ON FRESHWATER INFUSORIA JF - GEOMATE Journal JA - INTERNATIONAL JOURNAL OF GEOMATE VL - 11 IS - 23 SE - Articles DO - UR - https://geomatejournal.com/geomate/article/view/2520 SP - 2170-2176 AB - <p>Nanoparticle toxicology works toward establishing the hazard of nanoparticles, and therefore <br>their potential risk, in light of the increased use of exposure. The current study was research proper <br>characterization of the nanoparticles for understanding of their toxic effects and mechanisms at the cellular level. <br>Dose and time as a main parameters is essential in hazard identification and risk assessment of nanomaterials. <br>Material for the evaluation of toxic effects was used 20 samples of commercially available and laboratory <br>preparations of metals and nanocarbon, divided into main groups: carbon nanoparticles, metal oxide <br>nanoparticles and metal nanoparticles in different concentration. Fresh water infusoria stylonychia mytilus (wild<br>strain) in exponential growth phase was used as the test object. Analysis of data on oxides of the metals showed <br>higher toxicity than metal nanoparticles. In groups the maximum toxicity was observed in iron oxides (Fe3O4, <br>Fe2O3), copper (CuO) and molybdenum (MoO3) (0,1; 0,025; 0,0125 М) after 24 hours of incubation with the <br>test object Analysis of the effect of metal nanoparticles on the cells of infusoria showed that the maximum toxic <br>effect was observed when exposed to Cu, Fe, Ag (0,025- 0,0015625 М). Statistical analyses showed a high <br>correlation between concentration and time (P≤0,001). The issue of accessibility of nanomaterials released in the <br>environment for living organisms has been poorly studied. The toxic effects of nanoparticles can be associated <br>with their size and their physicochemical properties.</p> ER -