THE IMPACT OF EXPOSURE TO AEROSOL MOSQUITOES REPELLENT RELATED TO FREE RADICALS ON THE ORGANS OF MALE MICE

Abstract

From year to year, human activities using chemical substances lead to pollute ambient air and
affect human health. This pollutant can pass through the respiratory system and disrupts the organ function,
including lung, liver, blood, and kidney. It can be identified by the deformation found in the structure and
function change of the related cells in these organs and the existence of free radical. On the other hand, each
substance has a different composition and health effect. The possibility of the free radical type that is formed
is also different and related to the substance. According to this background, it a need to determine the
presence of free radicals in the mice’s organs exposed to one push aerosol mosquito repellents as the
substance. This study aimed to investigate the free radicals on the mice’s organs due to the exposure to
aerosol mosquito repellent and its relation with the organ damage of cell deformation. This study used male
mice as the experimental animals that were divided into control and treatment groups. The study included
two types of repellents, Type-A (25% of aerosol concentration) and Type-B (21.3% of aerosol
concentration). Free radicals were detected using an electron spin resonance device. The results showed that
the cell deformation due to the exposure of one push aerosol was different for each organ. The deformation
levels were about 36% to 74% that depended on the aerosol concentration. The exposed aerosol generated
anion superoxide (O2-) and singlet oxygen radicals (1O2) as the free radicals found in the observed organs.